How is rifampin typically administered at the start of first-line TB therapy?

How is rifampin typically administered at the start of first-line TB therapy?

• A. Orally on an empty stomach
• B. Orally with meals
• C. Intravenous
• D. Topical

Answer: (A)

Rifampin should be taken orally on an empty stomach to maximize absorption. Food, especially meals with fat, slows gastric emptying and lowers the drug’s bioavailability, which can reduce its effectiveness during the crucial early phase of treatment. If GI upset occurs, a light snack may be used, but absorption will still be somewhat reduced. If oral intake isn’t possible, rifampin can be given by intravenous route, but topical administration isn’t used for this drug.

Rifampin should be taken orally on an empty stomach to maximize absorption. Food, especially meals with fat, slows gastric emptying and lowers the drug’s bioavailability, which can reduce its effectiveness during the crucial early phase of treatment. If GI upset occurs, a light snack may be used, but absorption will still be somewhat reduced. If oral intake isn’t possible, rifampin can be given by intravenous route, but topical administration isn’t used for this drug.